The first book that shows in all its beauty, with a special photographic campaign, the largest floor mosaic in the world. A narration in images that starts from the Original Sin and continues between passages from the Bible and references to ancient history, almost a labyrinth between the vices and virtues of man. The book highlights the theological and iconographic meanings, with an interdisciplinary method in which historical, historical-artistic and theological knowledge converge, using the writings of the Fathers of the Church, elements of the religious culture of the land of Otranto, the knowledge of the theological thought of the XII century and the researches of religious and cultural anthropology. The comparison with the Arab and Jewish cultures, present in the Italo-Byzantine and Norman South, is also fruitful for the interpretation of some images. The study of cultural processes related to the symbol and iconographic interpretation allows, for example, to explain the presence of both real and fantastic animals and episodes belonging to non-biblical traditions. The comparison with works of art from the Latin and Byzantine Middle Ages allows us to understand the breadth of the cultural horizon in Otranto in the twelfth century. The result of this operation leads to reconsidering the general interpretation of the mosaic in a unitary and biblical sense, integrating the extra-biblical stories into the universal History of Salvation: the great tree, unifying center of the mosaic, takes on the characteristics of the Tree of Life, which marks and accompanies the Story of Salvation, from creative Wisdom to the Incarnation of the Son.